Publications

2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

CELL Program students are in bold.


2017

Freeman SA, Christian S, Austin P, Iu I, Graves ML, Huang L, Tang S, Coombs D, Gold MR, Roskelley CD (2017) Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor. Journal of Cell Science 130, 152-163.

Khong A, Kerr CH, Yeung CH, Keatings K, Nayak A, Allan DW, Jan E (2017) Disruption of stress granule formation by the multifunctional cricket paralysis virus 1A protein. Journal of Virology, doi: 10.1128/JVI.01779-16.

Templeman NM, Skovsø S, Page MM, Lim G, Johnson JD (2017) A causal role for hyperinsulinemia in obesity. Journal of Endocrinology; doi: 10.1530/JOE-16-0449.

Vent-Schmidt RY, Wen RH, Zong Z, Chiu CN, Tam BM, May CG, Moritz OL (2017) Opposing effects of valproic acid treatment mediated by histone deacetylase inhibitor activity in four transgenic X. laevis models of retinitis pigmentosa. Journal of Neuroscience 37, 1039-1054.


2016

Adams A, Vogl AW High resolution localization of Rab5, EEA1 and nectin-3 to tubulobulbar complexes in the rat testis (2016) Anatomical Record (accepted, Ms# AR-16-0234).

Aharoni-Simon M, Shumiatcher R, Yeung A, Shih AZ, Dolinsky VW, Doucette CA, Luciani DS (2016) Bcl-2 regulates reactive oxygen species signaling and a redox-sensitive mitochondrial proton leak in mouse pancreatic β-cells. Endocrinology 157, 2270-2281.

Bond SR, Abramyan J, Fu K, Naus CC, Richman JM (2016). Pannexin 3 is required for late stage bone growth but not for initiation of ossification in avian embryo. Developmental Dynamics 245, 913-924.

Bround MJ, Wambolt R, Cen H, Asghari P, Albu RF, Han J, McAfee D, Pourrier M, Scott NE, Bohunek L, Kulpa JE, Chen SRW, Fedida D, Brownsey RW, Borchers CH, Foster LJ, Mayor T, Moore ED, Allard MF, Johnson JD (2016) Ryr2-mediated calcium signals specifically promote glucose oxidation via pyruvate dehydrogenase. Journal of Biological Chemistry 291, 23490-23505.

Campbell S, Hoffman BG (2016) Chromatin regulators in pancreas development and diabetes. Trends in Endocrinology and Metabolism 27, 142-152.

Cao S, Wang JC, Gao J, Wong M, To E, White VA, Cui JZ, Matsubara JA (2016) CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation. British Journal of Ophthalmology 100, 713-718.

Chow LN, Schreiner P, Ng BY, Lo B, Hughes MR, Scott RW, Gusti V, Lecour S, Simonson E, Manisali I, Barta I, McNagny KM, Crawford J, Webb M, Underhill TM (2016) Impact of a CXCL12/CXCR4 antagonist in bleomycin (BLM) induced pulmonary fibrosis and carbon tetrachloride (CCl4) induced hepatic fibrosis in mice. PLoS One 11:e0151765.

D’Souza A, Johnson JD, Clee SM, Kieffer TJ (2016) Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient ob/ob mice. Molecular Metabolism 5, 1103-1112.

Denroche HC, Glavas MM, Tudurí E, Karunakaran S, Quong WL, Philippe M, Britton HM, Clee SM, Kieffer TJ (2016) Disrupted leptin signaling in the lateral hypothalamus and ventral premammillary nucleus alters insulin and glucagon secretion and protects against diet-induced obesity. Endocrinology 157, 2671-2685.

Denroche HC, Kwon MM, Glavas MM, Tuduri E, Philippe M, Quong WL, Kieffer TJ (2016) The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy. Molecular Metabolism. 5, 716-724.

Dionne DA, Skovsø S, Templeman NM, Clee SM, Johnson JD (2016) Caloric restriction paradoxically increases adiposity in mice with genetically reduced insulin. Endocrinology 157, 2724-2734.

D’Souza AM, Johnson JD, Clee SM, Kieffer T (2016) Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep ob/ob mice. Molecular Metabolism 5, 1103-1112.

Fairchild MJ, Yang L, Goodwin K, Tanentzapf G (2016) Occluding junctions maintain stem cell niche homeostasis in the fly testis. Current Biology 26, 2492–2499.

Goodwin K, Ellis SJ, Lostchuck E, Zulueta-Coarasa T, Fernandez-Gonzalez R, Tanentzapf G (2016) Basal cell-extracellular matrix adhesion regulates force transmission during tissue morphogenesis. Developmental Cell 39, 611-625.

Graves ML, Cipollone JA, Austin P, Bell EM, Nielsen JS, Gilks CB, McNagny KM, Roskelley CD (2016) The cell surface mucin podocalyxin regulates collective breast tumor budding. Breast Cancer Research 18:11, doi: 10.1186/s13058-015-0670-4.

Grist SM, Nasseri SS, Poon T, Roskelley C, Cheung KC (2016) On-chip clearing of assays of 3-D cell cultures and micro-tissues. Biomicrofluidics, 10:044107.

Holmes WR, Edelstein-Keshet L (2016) Analysis of a minimal Rho-GTPase circuit regulating cell shape. Physical Biology 13, 046001.

Holmes WR, Golding AE, Bement WM, Edelstein-Keshet L (2016) A mathematical model of GTPase pattern formation during single-cell wound repair. Royal Society Interface Focus 6, 20160032.

Khademolhosseini F, Liu CC, Lim CJ, Chiao M (2016) Magnetically actuated microstructured surfaces can actively modify cell migration behavior. Biomedical Microdevices 18, 13.

Kramer JL, Minhas NK, Jutzeler CR, Erskine EL, Liu LJ, Ramer MS (2016) Neuropathic pain following traumatic spinal cord injury: Models, measurement, and mechanisms. Journal of Neuroscience Research, doi: 10.1002/jnr.23881.

Lee K, Goh GYS, Wong MA, Klassen TL, Taubert S (2016) Gain-of-function alleles in Caenorhabditis elegans nuclear hormone receptor nhr-49 are functionally distinct. PLoS One 11(9):e0162708.

 López-Ceballos P, Herrera-Reyes AD, Coombs D, Tanentzapf G (2016) In vivo regulation of integrin turnover by outside-in activation. Journal of Cell Science 129, 2912-2924.

Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, Roskelley C, Forge T, Nislow C, Moerman D (2016) Using C. elegans forward and reverse genetics to identify new compounds with anthelmintic activity. PLoS Neglected Tropical Diseases 10, e0005058.

Naus CC, Aftab Q, Sin WC (2016) Common mechanisms linking connexin43 to neural progenitor cell migration and glioma invasion. Seminars in Cell and Developmental Biology, 50, 59-66.

Neumann UH, Denroche HC, Mojibian M, Covey SD, Kieffer TJ (2016) Insulin knockout mice have extended survival but volatile blood glucose levels on leptin therapy. Endocrinology 157, 1007-1012.

Neumann UH, Ho JSS, Mojibian M, Covey SD, Charron MJ, Kieffer TJ (2016) Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival. Molecular Metabolism 5, 731-736.

Oudhoff MJ, Bream MJ, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Rafaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FM, Tatlock JH, Owen DR, Brown PJ, Zaph C (2016) SETD7 controls intestinal regeneration and tumorigenesis by regulating Wnt/β-catenin and Hippo/YAP signaling. Developmental Cell 37, 47-57.

Porubský D, Sanders AD, van Wietmarschen N, Falconer E, Hills M, Spierings DC, Bevova MR, Guryev V, Lansdorp PM (2016) Direct chromosome-length haplotyping by single-cell sequencing. Genome Research 26, 1565-1574.

Sanders AD, Hills M, Porubský D, Guryev V, Falconer E, Lansdorp PM (2016) Characterizing polymorphic inversions in human genomes by single-cell sequencing. Genome Research 26, 1575-1587.

Scott RW, Underhill TM (2016) Methods and strategies for lineage tracing of mesenchymal progenitor cells. Methods in Molecular Biology 1416, 171-203.

Shin JJ, Aftab Q, Austin P, McQueen JA, Poon T, Li SC, Young BP, Roskelley CD, Loewen CJ (2016) Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets. Disease Models and Mechanisms 9, 1039-1049.

Sin WC, Aftab Q, Bechberger J, Leung J, Chen H, Naus CC (2016) Astrocytes promote glioma invasion via the gap junction protein connexin43. Oncogene 35, 1504-1516.

Speckmann T, Sabatini PV, Nian C, Smith RG, Lynn FC (2016) Npas4 transcription factor expression Is regulated by calcium signaling pathway and prevents tacrolimus-induced cytotoxicity in pancreatic beta cells. Journal of Biological Chemistry 291, 2682-2695.

Szabat M, Page MM, Panzhinskiy E, Skovsø S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ, Lee JT, Xu EE, Taghizadeh F, O’Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC, Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD (2016) Reduced insulin production relieves endoplasmic reticulum stress and induces β cell proliferation. Cell Metabolism 23, 179-193.

Templeman NM, Mehran AE, Hu X, Johnson JD (2016) Hyper-variability in circulating insulin and physiological outcomes in male high fat-fed Ins1-/-:Ins2+/- mice in a specific pathogen-free facility. PLoS One; http://dx.doi.org/10.1371/journal.pone.0153280.

Tennant B, Vanderkruk B, Dhillon J, Dai D, Verchere B, Hoffman BG (2016) Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction. Cell Death and Disease 7, e2233.

Tham DK, Joshi B, Moukhles H (2016) Aquaporin-4 cell-surface expression and turnover are regulated by dystroglycan, dynamin, and the extracellular matrix in astrocytes. PLoS One 11, e0165439.

Timbers TA, Garland SJ, Mohan S, Flibotte S, Edgley M, Muncaster Q, Au V, Li-Leger E, Rosell FI, Cai J, Rademakers S, Jansen G, Moerman DG, Leroux MR (2016) Accelerating gene discovery by phenotyping whole-genome sequenced multi-mutation strains and using the sequence kernel association test (SKAT). PLoS Genetics 12, e1006235

Vent-Schmidt RY, Wen RH, Zong Z, Chiu CN, May CG, Tam BM, Moritz OL (2016) Opposing effects of valproic acid treatment mediated by histone deacetylase inhibitor activity in four transgenic X. laevis models of retinitis pigmentosa. Journal of Neuroscience 1647-16.2016.

Whitfield ST, Burston HE, Bean BD, Raghuram N, Maldonado-Báez L, Davey M, Wendland B, Conibear E (2016) The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting. Molecular Biology of the Cell 27, 588-598.


2015

Adams WK, Sussman JL, Kaur S, D’Souza AM, Kieffer TJ, Winstanley CA (2015) Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling – two markers of addiction vulnerability. European Journal of Neuroscience 42, 3095-3104.

Aftab Q, Sin WC, Naus CC (2015) Reduction in gap junction intercellular communication promotes glioma migration. Oncotarget 6:11447-11464.

Albrecht T, Zhao Y, Nguyen TH, Campbell RE, Johnson JD (2015) Fluorescent biosensors illuminate calcium levels within defined beta-cell endosome subpopulations. Cell Calcium 57, 263-274.

Berndt AJ, Tang JC, Ridyard MS, Lian T, Keatings K, Allan DW (2015) Gene regulatory mechanisms underlying the spatial and temporal regulation of target-dependent gene expression in Drosophila neurons. PLoS Genetics 11:e1005754.

Bogéa TH, Wen RH, Moritz OL (2015) Light induces ultrastructural changes in rod outer and inner segments, including autophagy, in a transgenic Xenopus laevis P23H rhodopsin model of retinitis pigmentosa. Investigative Ophthalmology & Visual Science 56, 7947-7955.

Dalton L, Davey M, Conibear E (2015) Large-scale analysis of membrane transport in yeast using invertase reporters. Methods Molecular Biology 1270, 395-409.

Denk F, Ramer LM, Erskine EL, Nassar MA, Bogdanov Y, Signore M, Wood JN, McMahon SB, Ramer MS (2015). Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis. Acta Neuropathologica Communications 3, 74.

Denroche HC, Kwon MM, Quong WL, Neumann UH, Kulpa JE, Karunakaran S, Clee SM, Brownsey RW, Covey SD, Kieffer TJ (2015) Leptin induces fasting hypoglycaemia in diabetic mice through the depletion of glycerol. Diabetologia 58, 1100-1108.

Ding W, Smulan LJ, Hou NS, Taubert S, Watts JL, Walker AK (2015) S-adenosylmethione levels govern innate immunity through distinct methylation-dependent pathways. Cell Metabolism 22, 633-645.

Fairchild MJ, Smendziuk C, Tanentzapf G (2015) A somatic permeability barrier around the germline is essential for Drosophila spermatogenesis. Development 142, 268-281.

Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR (2015) Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nature Communications 6, 6168. doi:10.1038/ncomms7168.

Gage BK Asadi A, Baker RK, Webber TD, Wang R, Itoh M, Hayashi M, Miyata R, Akashi T, Kieffer TJ (2015) The role of ARX in human pancreatic endocrine specification. PloS One 10, e0144100.

Gao J, Liu RT, Cao S, Cui JZ, Wang A, To E, Matsubara JA (2015) NLRP3 inflammasome: activation and regulation in age-related macular degeneration. Mediators of Inflammation 2015:690243. doi: 10.1155/2015/690243.

Garside VC, Cullum R, Alder O, Lu DY, Vander Werff R, Bilenky M, Zhao Y, Jones SJ, Marra MA Underhill TM, Hoodless PA (2015) SOX9 modulates the expression of key transcription factors required for heart valve development. Development 142, 4340-4350.

Grants JM, Goh GYS, Taubert S. (2015) The Mediator complex of Caenorhabditis elegans. Nucleic Acids Research 43, 2442-2453.

Hákonardóttir GK, López-Ceballos P, Herrera-Reyes AD, Das R, Coombs D, Tanentzapf G (2015) In vivo quantitative analysis of talin turnover in response to force. Molecular Biology of the Cell 26, 4149-4162.

Ho MM, Johnson JD, Clee SM (2015) PWD/PhJ mice have a genetically determined increase in nutrient-stimulated insulin secretion. Mammalian Genome 26, 131-141.

Holmes WR, Liao L, Bement B, Edelstein-Keshet L (2015) Modeling the role of protein kinase C eta and beta in single cell wound repair. Molecular Biology of the Cell 26, 4100-4108.

Hutter H, Moerman D (2015) Big data in Caenorhabditis elegans: quo vadis? Molecular Biology of the Cell 26, 3909-3914.

Kerr CH, Wang QS, Keatings K, Khong A, Allan D, Yip CK, Foster LJ, Jan E (2015) The 5′ untranslated region of a novel infectious molecular clone of the Dicistrovirus Cricket Paralysis Virus modulates infection. Journal of Virology 89, 5919-5934.

Konorov SO, Schulze HG, Gage BK, Kieffer TJ, Piret JM, Blades MW, Turner RF (2015) Process analytical utility of raman microspectroscopy in the directed differentiation of human pancreatic insulinpositive cells. Analytical Chemistry 87, 10762-10769.

Kwon MM, O’Dwyer SM, Baker RK, Covey SD, Kieffer TJ (2015) FGF21-mediated improvements in glucose clearance require uncoupling protein 1. Cell Reports 13, 1521-1527.

Li L, Gao G, Shankar J, Joshi B, Nabi IR (2015) p38MAP kinase regulation of Gp78 E3 ubiquitin ligase activity. Molecular Biology of the Cell 26, 3828-3840.

Liang X, Dong X, Moerman DG, Shen K, Wang X (2015) Sarcomeres pattern proprioceptive sensory dendritic endings through UNC-52/Perlecan in C. elegans. Developmental Cell 33, 388-400.

Lim GE, Albrecht T, Piske M, Sarai K, Lee JTC, Ramshaw HS, Sinha S, Guthridge MA, Acker-Palmer A, Lopez AF, Clee SM, Nislow C, Johnson JD (2015) 14-3-3z coordinates adipogenesis of visceral fat. Nature Communications 6, 7671. doi: 10.1038/ncomms8671.

Meng F, Joshi B, Nabi IR (2015) PTRF/Cavin-1 interacts with galectin-3 to control caveolin-1-dependent migration of PC3 prostate cancer cells. PLoS One 10, e0126056.

Nimmagadda S, Buchtova M, Fu K, Geetha-Loganathan P, Hosseini-Farahabadi S, Trachtenberg AJ, Kuo WP, Vesela I, Richman JM (2015) Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo. Developmental Biology 407, 275-288.

Racacho L, Byrnes AM, MacDonald H, Dranse HJ, Nikkel SM, Allanson J, Rosser E, Underhill TM, Bulman DE (2015) Two novel disease-causing variants in BMPR1B are associated with brachydactyly type A1. European Journal of Human Genetics 23, 1640-1645.

Sabatini PV, Lynn FC (2015) All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes. Trends in Endocrinology and Metabolism 26, 49-57.

Sanders SS, Hou J, Sutton LM, Garside VC, Mui KK, Singaraja RR, Hayden MR, Hoodless PA (2015) Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development. Developmental Biology 397, 257-266.

Smendziuk CM, Messenberg A, Vogl AW, Tanentzapf G (2015) Bi-directional gap junction-mediated soma-germline communication is essential for spermatogenesis. Development 142, 2598-2609.

Snyder KA, Hughes MR, Hedberg B, Brandon J, Hernaez DC, Bergqvist P, Cruz E, Po K, Graves ML, Turvey ME, Nielsen JS, Wilkins JA, McColl SR, Babcook JS, Roskelley CD, McNagny KM (2015) Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy. Breast Cancer Research 17:46.

Szabat M, Modi H, Ramracheya R, Girbinger V, Chan F, Lee JTC, Piske M, Kamal S, Yang YHC, Welling A, Rorsman P, Johnson JD (2015) High-content screening identifies a role for Na+ channels in insulin production. Royal Society Open Science 2, 150306. doi: 10.1098/rsos.150306.

Tam BM, Yang LL, Bogėa TH, Ross B, Martens G, Moritz OL (2015) Preparation of Xenopus laevis retinal cryosections for electron microscopy. Experimental Eye Research 136, 86-90.

Templeman NM, Clee SM, Johnson JD (2015) Transient suppression of hyperinsulinemia in growing female mice provides long-term protection against obesity. Diabetologia 58, 2392-2402.

Tennant BR, Chen J, Shih AZ, Luciani DS, Hoffman BG (2015) Myt3 mediates laminin-V/integrin-β1-induced islet-cell migration via Tgfbi. Molecular Endocrinology 29, 1254-1268.

Tennant B, Hurley P, Gill A, Whiting C, Hoffman BG (2015) The TrxG complex mediates cytokine induced de novo enhancer formation in islets. PLoS One 10, e0141470.

Wang JC, Cao S, Wang A, To E, Law G, Gao J, Zhang D, Cui JZ, Matsubara JA (2015) CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye. Molecular Vision 21, 264-272.

Wang PTC, Garcin PO, Fu M, Masoudi M, Panté N, Nabi IR (2015) Autocrine motility factor regulates Gp78 ubiquitin ligase endoplasmic reticulum-mitochondria coupling. Journal of Cell Science 128, 2759-2765.

Xu EE, Krentz NA, Tan S, Chow SZ, Tang M, Nian C, Lynn FC (2015) SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia 58, 1013-1023.

Yang YHC, Wills QF, Johnson JD (2015) A live-cell, high-content imaging survey of 206 endogenous factors across five stress conditions reveals context-dependent survival effects in mouse primary beta cells. Diabetologia 58, 1239-1249.

Zhao T, Gao J, Van J, To E, Wang A, Cao S, Cui JZ, Guo JP, Lee M, McGeer PL, Matsubara JA (2015) Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye. Journal of Neuroinflammation 12, 121. doi: 10.1186/s12974-015-0337-1.


2014

Agbaga MP, Tam BM, Wong JS, Yang LL, Anderson RE, Moritz OL (2014) Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks. Investigative Ophthalmology & Visual Science 55, 3669-3680.

Albu RF, Chan GT, Zhu M, Wong ETC, Taghizadeh F, Hu X, Mehran AE, Johnson JD, Gsponer J, Mayor T (2014) A feature analysis of lower solubility proteins in three eukaryotic systems. Journal of Proteomics 118, 21-38.

Alder O, Cullum R, Lee S, Kan AC, Wei W, Yi Y, Garside VC, Bilenky M, Griffith M, Morrissy AS, Robertson GA, Thiessen N, Zhao Y, Chen Q, Pan D, Jones SJ, Marra MA, Hoodless PA (2014) Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation. Cell Reports 9, 261-271.

Asghari P, Scriven DR, Sanatani S, Gandhi SK, Campbell AI, Moore EDW (2014) Non-uniform and variable arrangements of ryanodine receptors within mammalian ventricular couplons. Circulation Research 115, 252-26.

Bond S, Naus CC (2014) The pannexins: past and present. Frontiers in Physiology 5, 58.

Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S (2014) Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Nature Communications 5:5511.

Chan MT, Lim GE, Skovsø S, Yang YHC, Albrecht T, Alejandro EU, Hoesli C, Piret JM, Warnock GL, Johnson JD (2014) Effects of insulin on human pancreatic cancer progression modeled in vitro. BMC Cancer 14, 814.

Chang AC, Garside VC, Fournier M, Smrz J, Vrljicak P, Umlandt P, Fuller M, Robertson G, Zhao Y, Tam A, Jones SJ, Marra MA, Hoodless PA, Karsan A (2014) A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Developmental Dynamics 243, 894-905.

Chao JT, Wong AKO, Tavassoli S, Young BP, Chruscicki A, Fang NN, Howe LJ, Mayor T, Foster LJ, Loewen CJR (2014) Polarization of the Endoplasmic Reticulum by ER-Septin Tethering. Cell 158, 620-632.

D’Souza AM, Asadi A, Johnson JD, Covey SD, Kieffer TJ (2014) Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis. Endocrinology 155, 1268-1279.

Ellis SJ, Lostchuck E, Goult BT, Bouaouina M, Fairchild MJ, López-Ceballos P, Calderwood DA, Tanentzapf G (2014) The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering. PLoS Genetics 10(11):e1004756.

Falk L, Dang-Lawson M, Vega Pizzaro JL, Pournia F, Choi K, Jang C, Naus CC, Matsuuchi L (2014) Mutations of Cx43 that effect B cell spreading in response to BCR signaling. Biology Open 3, 185-194.

Gage BK, Baker RK, Kieffer TJ (2014) Overexpression of PAX4 reduces glucagon expression in differentiating hESCs. Islets 6(2):e29236.

Garaulet DL, Castellanos MC, Bejarano F, Sanfilippo P, Tyler DM, Allan DW, Sánchez-Herrero E, Lai EC (2014) Homeotic function of Drosophila Bithorax-complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the CNS. Developmental Cell 29, 635-648.

Goh GYS, Martelli KL, Parhar KS, Kwong AW, Wong MA, Mah A, Hou NS, Taubert S (2014) The conserved Mediator subunit MDT-15 is required for oxidative stress responses in C. elegans. Aging Cell 13, 70-79.

Ho MM, Hu X, Karunakaran S, Johnson JD, Clee SM (2014) Altered pancreatic growth and insulin secretion in WSB/EiJ mice. PLoS One 9(2):e88352.

Hou J, Wei W, Saund RS, Xiang P, Cunningham TJ, Yi Y, Alder O, Lu DY, Savory JG, Krentz NA, Montpetit R, Cullum R, Hofs N, Lohnes D, Humphries RK, Yamanaka Y, Duester G, Saijoh Y, Hoodless PA (2014) A regulatory network controls nephrocan expression and midgut patterning. Development 141, 3772-3781.

Hou NS, Gutschmidt A, Choi DY, Pather K, Shi X, Watts JL, Hoppe T, Taubert S (2014) Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proceedings of the National Academy of Sciences USA 111, E2271-E2280.

Hou NS, Taubert S (2014) Membrane lipids and the endoplasmic reticulum unfolded protein response: a complicated relationship. Worm 3(3):e962405-1-5.

Krentz NA, Nian C, Lynn FC (2014) TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. PLoS One 9(12):e114275.

Lahiri S, Chao JT, Tavassoli S, Wong AKO, Choudhary V, Young BP, Loewen CJR, Prinz WA (2014) A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. PLoS Biology 12:e1001969.

Leclair P, Lim CJ (2014) CD47-independent effects mediated by the TSP-derived 4N1K peptide. PLoS One 9(5):e98358.

Liu RT, Wang A, To E, Gao J, Cao S, Cui JZ, Matsubara JA (2014) Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells. Experimental Eye Research 127, 49-58.

Liu Y, Wang R, Sun B, Mi T, Zhang J, Mu Y, Chen J, Bround MJ, Johnson JD, Gillis A, Chen SRW (2014) Generation and characterization of a knock-in mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor. PLoS One 9(4):e95615.

Machtaler S, Choi K, Dang-Lawson M, Falk L, Pournia F, Naus CC, Matsuuchi L (2014) The role of the gap junction protein connexin43 in B lymphocyte motility and migration. FEBS Letters 588, 1249-1258.

Mah W, Jiang G, Olver D, Cheung G, Kim B, Larjava H, Häkkinen L (2014) Human gingival fibroblasts display a non-fibrotic phenotype distinct from skin fibroblasts in three-dimensional cultures. PLoS One 9(3):e90715.

Neumann UH, Chen S, Tam YY, Baker RK, Covey SD, Cullis PR, Kieffer TJ (2014) IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice. Endocrinology 155, 716-725.

Ngai YF, Sabatini P, Nguyen D, Davidson J, Chanoine JP, Devlin AM, Lynn FC, Panagiotopoulos C (2014) Quetiapine treatment in youth is associated with decreased insulin secretion. Journal of Clinical Psychopharmacology 34, 359-364.

Perkins AD, Lee MJJ, Tanentzapf G (2014) The systematic identification of cytoskeletal genes required for Drosophila melanogaster muscle maintenance. Scientific Data 1:140002. doi:10.1038/sdata.2014.2.

Perkins AD, Tanentzapf G (2014) An ongoing role for structural sarcomeric components in maintaining Drosophila melanogaster muscle function and structure. PLOS One 9(6):e99362.

Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O’Dwyer S, Quiskamp N, Mojibian M, Albrecht T, Yang YH, Johnson JD, Kieffer TJ (2014) Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nature Biotechnology 32, 1121-1133.

Roundtree A, Neal AS, Lisowski M, Rizzo N, Radtke J, White SA, Luciani DS, Kim F, Hampe CS, Sweet IR (2014) Control of insulin secretion by cytochrome c and calcium signaling in islets with impaired metabolism. Journal of Biological Chemistry 289, 19110-19119.

Tudurí E, Denroche HC, Kara JA, Asadi A, Fox JK, Kieffer TJ (2014) Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis. American Journal of Physiology (Endocrinology and Metabolism) 306, E748-755.

Underhill TM, Dranse HJ, Hoffman LM (2014) Analysis of chondrogenesis using micromass cultures of limb mesenchyme. Analysis of skeletal development using cell and organ culture model systems. Methods in Molecular Biology 1130, 251-265.

Vogl AW, Du M, Wang XY, Young JS (2014) Novel clathrin/actin-based endocytic machinery associated with junction turnover in the seminiferous epithelium. Seminars in Cell and Developmental Biology 30, 55-64.

Wong AK, Chao JT, Loewen CJ (2014) Barriers to uniformity within the endoplasmic reticulum. Current Opinion in Cell Biology 29, 31-38.

Yang YHC, Vilin YY, Roberge M, Kurata HT, Johnson JD (2014) Multi-parameter screening reveals a role for Na+ channels in cytokine-induced beta-cell death. Molecular Endocrinology 28, 406-417.

Zheng JC, Tham CT, Keatings K, Fan S, Liou AY, Numata Y, Allan D, Numata M (2014) Secretory Carrier Membrane Protein (SCAMP) deficiency influences behavior of adult flies. Frontiers in Cell and Developmental Biology 2, 64. doi: 10.3389/fcell.2014.00064.


2013

Austin P, Freeman SA, Gray CA, Gold MR, Vogl AW, Andersen RJ, Roberge M, Roskelley CD (2013) The invasion inhibitor sarasinoside A1 reverses mesenchymal tumor transformation in an E-cadherin-independent manner. Molecular Cancer Research 11, 530-540.

Bozorgmehr T, Ardiel EL, McEwan AH, Rankin CH (2013) Mechanisms of plasticity in a Caenorhabditis elegans mechanosensory circuit. Frontiers in Physiology 4:88, doi: 10.3389/fphys.2013.00088.

Bround MJ, Wambolt R, Luciani DS, Kulpa JE, Rodrigues B, Brownsey RW, Allard MF, Johnson JD (2013) Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo. Journal of Biological Chemistry 288, 18975-18986.

Caron NJ, Gage BK, O’Connor MD, Eaves CJ, Kieffer TJ, Piret JM (2013) A human embryonic stem cell line adapted for high throughput screening. Biotechnology and Bioengineering 110, 2706-2716.

Castellanos MC, Tang JC, Allan DW (2013) Female-biased dimorphism underlies a female-specific role for post-embryonic Ilp7 neurons in Drosophila fertility. Development 140, 3915-3926.

Daoust J, Chen M, Wang M, Williams DE, Chavez MA, Wang YA, Merchant CE, Fontana A, Kieffer TJ, Andersen RJ (2013) Sesterterpenoids isolated from a northeastern pacific Phorbas sp. Journal of Organic Chemistry 78, 8267-8273.

Denroche HC, Quong WL, Bruin JE, Tudurí E, Asadi A, Glavas MM, Fox JK, Kieffer TJ (2013) Leptin administration enhances islet transplant performance in diabetic mice. Diabetes 62, 2738-2746.

Du M, Young J, De Asis M, Cipollone J, Roskelley CD, Takai Y, Nicholls PK, Stanton PG, Deng W, Finlay BB, Vogl AW (2013) A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium. Biology of Reproduction 88, 60.

Ellis SJ, Goult BT, Fairchild MJ, Harris NJ, Long J, Lobo P, Czerniecki S, van Petegem F, Schoeck F, Peifer M, Tanentzapf G (2013) Talin autoinhibition is required for morphogenesis. Current Biology 23, 1825-1833.

Erener S, Mojibian M, Fox JK, Denroche HC, Kieffer TJ (2013) Circulating miR-375 as a biomarker of β-cell death and diabetes in mice. Endocrinology 154, 603-608.

Foti SB, Chou A, Moll AD, Roskams AJ (2013) HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain. International Journal of Developmental Neuroscience 31, 434-447.

Fu M, St. Pierre P, Shankar J, Wang PTC, Joshi B, Nabi IR (2013) Regulation of mitophagy by the Gp78 E3 ubiquitin ligase. Molecular Biology of the Cell 24, 1153-1162.

Gage BK, Webber TD, Kieffer TJ (2013) Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells. PLoS One 8(12):e82076.

Garside VC, Chang AC, Karsan A, Hoodless PA (2013) Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development. Cellular and Molecular Life Sciences 70, 2899-2917.

Gielen PR, Aftab Q, Maa N, Chen VC, Hong X, Lozinsky S, Naus CC, Sin WC (2013) Cx43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway. Neuropharmacology 75, 539-548.

Ho M, Yoganathan P, Chu KY, Karunakaran S, Johnson JD, Clee SM (2013) Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and glucose concentrations in islets. BMC Genetics 14, 10.

Hosseini-Farahabadi S, Geetha-Loganathan P, Fu K, Nimmagadda S, Yang HJ, Richman JM (2013) Dual functions for WNT5A during cartilage development and in disease. Matrix Biology 32, 252-264.

Huynh FK, Neumann UH, Wang Y, Rodrigues B, Kieffer TJ, Covey SD (2013) A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. Hepatology 57, 543-554.

Lau HL, Timbers TA, McEwan AH, Bozorgmehr T, Rankin CH (2013) Genetic dissection of memory for associative and non-associative learning in C. elegans. Genes, Brain and Behavior 12, 210-223.

Li C, Timbers TA, Rose JK, Bozorgmehr T, McEwan A, Rankin CH (2013) The FMRFamide-related neuropeptide FLP-20 is required in the mechanosensory neurons during memory for massed training in C. elegans. Learning and Memory 20, 103-108.

Liu CC, Leclair P, Yap SQ, Lim CJ (2013) The membrane proximal KxGFFKR motif of α-Integrin mediates chemoresistance. Molecular and Cellular Biology 33, 4334-4345.

Liu RT, Gao J, Cao S, Sandhu N, Cui JZ, Chou CL, Fang E, Matsubara JA (2013) Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration. Investigative Ophthalmology & Visual Science 54, 2225-2237.

Luciani DS, White SA, Widenmaier S, Saran V, Taghizadeh F, Xiaoke H, Allard MF, Johnson JD (2013) Bcl-2 and Bcl-xL suppress glucose signalling in pancreatic β-cells. Diabetes 62, 170-182.

Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, Zaph C (2013) Control of the hippo pathway by Set7-dependent methylation of Yap. Developmental Cell 26, 188-194.

Ruozhou TL, Gao J, Cao S, Sandhu N, Cui JZ, Chou CL, Fang E, Matsubara JA (2013) Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: Implications for inflammasome activation in age-related macular degeneration. Investigative Ophthalmology and Visual Science 54, 2225-2237.

Sabatini PV, Krentz NA, Zarrouki B, Westwell-Roper CY, Nian C, Uy RA, Shapiro AM, Poitout V, Lynn FC (2013) Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells. Diabetes 62, 2808-2820.

Scriven DR, Asghari P, Moore EDW (2013) Microarchitecture of the dyad. Cardiovascular Research 98, 169-176.

Shankar J, Kojic LD, St-Pierre P, Wang PT, Fu M, Joshi B, Nabi IR (2013) Raft endocytosis of AMF regulates mitochondrial dynamics through Rac1 signaling and the Gp78 ubiquitin ligase. Journal of Cell Science 126, 3295-3304.

Tavassoli S, Chao JT, Young BP, Cox RC, Prinz WA, de Kroon AIPM, Loewen CJR (2013) Plasma membrane-endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis. EMBO Reports 14, 434-440.

Tennant BR, Robertson G, Beach M, Li L, Zhang X, Kramer MM, Thiessen N, Mungall K, Whiting C, Kim A, Gottardo R, Marra M, Lynn F, Jones S, Hoodless P, Hoffman BG (2013) Identification and analysis of pancreatic islet specific enhancers. Diabetologia 56, 542-552.

Tudurí E, Bruin JE, Denroche HC, Fox JK, Johnson JD, Kieffer TJ (2013) Impaired Ca2+ signaling in β-cells lacking leptin receptors by Cre-loxP recombination. PLoS One 8(8):e71075.

Veverytsa L, Allan DW (2013) Subtype-specific neuronal remodeling during Drosophila metamorphosis. Fly 7, 78-86.

Vogl AW, Young JS, Du M (2013) New insights into roles of tubulobulbar complexes in sperm release and turnover of blood-testis barrier. International Review of Cell and Molecular Biology 303, 319-355.

Wang N, De Vuyst E, Ponsaerts R, Boengler K, Palacios-Prado N, Wauman J, Lai CP, De Bock M, Decrock E, Bol M, Vinken M, Rogiers V, Tavernier J, Evans WH, Naus CC, Bukauskas F, Sipidio KR, Heusch G, Schulz R, Bultynck G, Leybaert L (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Research in Cardiology 108, 309.

Yang YH, Manning Fox JE, Zhang KL, MacDonald PE, Johnson JD (2013) Intra-islet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion. Proceedings of the National Academy of Sciences USA 110, 16480-16485.

Yang YHC, Johnson JD (2013) Multi-parameter, single-cell, kinetic imaging reveals multiple cell death modes in primary pancreatic beta-cells. Journal of Cell Science 126, 4286-4295.

Zhang D, Wan A, Chiu AP, Wang Y, Wang F, Neumaier K, Lal N, Bround MJ, Johnson JD, Vlodavsky I, Rodrigues B (2013) Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase. Arteriosclerosis, Thrombosis and Vascular Biology 33, 2830-2838.

Zhou L, MacDonald G, Graves M, Mueller C, Roskelley CD (2013) Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in pre-malignant human ovarian surface epithelial cells. Molecular Cancer Research 11, 272-281.


2012

Asghari P, Scriven DRL, Hoskins J, Fameli N, van Breemen C, Moore EDW (2012) The structure and functioning of the couplon in mammalian cardiomyocytes. Protoplasma 249 (Suppl. 1), S31-S38.

Bao BA, Lai CPK, Naus CC, Morgan JR (2012) Pannexin1 drives multicellular aggregate compaction via a signaling cascade that upregulates cytoskeletal function. Journal of Biological Chemistry 287, 8407-8416.

Bond SR, Naus CC (2012) RF-Cloning.org: an online tool for the design of restriction-free cloning projects. Nucleic Acid Research 40, W209-W213.

Bond SR, Wang N, Leybeart L, Naus CC (2012) Pannexin 1 ohnologs in the teleost lineage. Journal of Membrane Biology 245, 483-493.

Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schoeck F, Calderwood D (2012) Zasp regulates integrin activation. Journal of Cell Science 125, 5647-5657.

Bround MJ, Asghari P, Wambolt R, Bohunek L, Smits C, Philit M, Kieffer TJ, Lakatta EG, Boheler KR, Moore EDW, Allard MF, Johnson JD (2012) Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice. Cardiovascular Research 96, 372-380.

Cho YM, Merchant CE, Kieffer TJ (2012) Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacology and Therapeutics 135, 247-278.

Cipollone J, Graves M, Koebel M, Kalloger SE, Poon T, Gilks CB, McNagny KM, Roskelley CD (2012) The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma. Clinical and Experimental Metastasis 29, 239-252.

Denroche HC, Huynh FK, Kieffer TJ (2012) The role of leptin in glucose homeostasis. Journal of Diabetes Investigation 3, 115-129.

Eade KT, Fancher HA, Ridyard MS, Allan DW (2012) Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system. PLoS Genetics 8(2): e1002501.

Fairbank M, Huang K, El-Husseini A, Nabi IR (2012). RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase. FEBS Letters 586, 2488-2493.

Falconer E, Hills M, Naumann U, Poon SS, Chavez EA, Sanders AD, Zhao Y, Hirst M, Lansdorp PM (2012) DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nature Methods 9, 1107-1112.

Hou NS, Taubert S (2012) Function and regulation of lipid biology in Caenorhabditis elegans aging. Frontiers in Physiology 3:143.

Jiang K, To E, Cui JZ, Cao S, Gao J, Matsubara JA (2012) Drusen and pro-inflammatory mediators in the post-mortem human eye. Journal of Clinical and Experimental Ophthalmology 3, 208.

Joshi B, Bastiani M, Strugnell SS, Boscher C, Parton RG, Nabi IR (2012) Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation. Journal of Cell Biology 199, 425-435.

Levi J, Huynh FK, Denroche H, Neumann UH, Glavas MM, Covey SD, Kieffer TJ (2012) Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGFBP-2 in ob/ob mice. Diabetologia 55, 752-762.

Mehran A, Tempelman NM, Brigidi S, Lim GE, Chu K-Y, Botezelli JD, Hu X, Asadi A, Hoffman BG, Kieffer TJ, Bamji SX, Clee SM, Johnson JD (2012) Hyperinsulinemia drives diet-induced obesity independently of brain insulin. Cell Metabolism 16, 723-737.

Pines M, Das R, Ellis SJ, Morin A, Czerniecki S, Yuan L, Klose M, Coombs D, Tanentzapf G (2012) Mechanical force regulates integrin turnover in Drosophila in vivo. Nature Cell Biology 14, 935-943.

Shankar J, Wiseman SM, Meng F, Kasaian K, Strugnell SS, Mofid A, Gown A, Jones SJ, Nabi IR (2012) Coordinated expression of galectin-3 and caveolin-1 in thyroid cancer. Journal of Pathology 228, 56-66.

Tennant BR, Islam R, Kramer MM, Merkulova Y, Kiang R, Whiting C, Hoffman BG (2012) The transcription factor Myt3 acts as a pro-survival factor in β-cells. PLoS One 7(12):e51501.

Veverytsa L, Allan DW (2012) Temporally tuned neuronal differentiation supports the functional remodeling of a neuronal network in Drosophila. Proceedings of the National Academy of Sciences USA 109, E748-E756.

Wang JCC, Wang G, Gao J, Cao S, Samad I, Zhang D, Ritland C, Cui JZ, Matsubara JA (2012) Technical Brief: Isolation of total DNA from postmortem human eye tissues and quality comparison between iris and retina. Molecular Vision 18, 3049-3056.

Yoganathan P, Karunakaran S, Ho MM, Clee SM (2012) Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner. Nutrition and Metabolism 9, 65.

Young JS, de Asis M, Guttman J, Vogl AW (2012) Cortactin depletion results in short tubulobulbar complexes and spermiation failure in rat testes. Biology Open 1, 1-9.

Young JS, Takai Y, Kojic KL, Vogl AW (2012) Internalization of adhesion junction proteins and their association with recycling endosome marker proteins in rat seminiferous epithelium. Reproduction 143, 1-12.

Young JS, Vogl AW (2012) Focal adhesion proteins zyxin and vinculin are co-distributed at tubulobulbar complexes. Spermatogenesis 2, 1-6.


2011

Aiga M, Levinson JN, Yoshida E, Bamji SX (2011) N-cadherin and neuroligins cooperate to regulate synapse formation in hippocampal cultures. Journal of Biological Chemistry 286, 851-858.

Alejandro EU, Lim GE, Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD (2011) Pancreatic beta-cell Raf-1 is required for glucose tolerance, insulin secretion and insulin 2 transcription. FASEB Journal 25, 3884-3895.

Bond SR, Lau A, Penuela S, Sampaio AV, Underhill TM, Laird DW, Naus CC (2011) Pannexin3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. Journal of Bone and Mineral Research 26, 2911-2922.

Chang AC, Fu Y, Garside VC, Niessen K, Chang L, Fuller M, Setiadi A, Smrz J, Kyle A, Minchinton A, Marra M, Hoodless PA, Karsan A (2011) Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase. Developmental Cell 21, 288-300.

Chu KY, Briggs MJL, Albrecht T, Drain PF, Johnson JD (2011) Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells. Islets 3, 155-165.

Denroche HC, Levi J, Covey SD, Wideman RD, Sequeira R, Kieffer TJ (2011) Leptin therapy reverses diabetes in STZ-diabetic mice, independent of hepatic leptin signaling. Diabetes 60, 1414-1423.

Dranse H, Sampaio AV, Petkovich MP, Underhill TM (2011) Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis. Journal of Cell Science 124, 2723-2734.

Ellis SJ, Pines M, Fairchild MJ, Tanentzapf G (2011) In vivo functional analysis reveals specific roles for the integrin binding sites of talin. Journal of Cell Science 124, 1844-1856.

Freeman SA, Lei V, Dang-Lawson M, Mizuno K, Roskelley CD, Gold MR (2011) Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation. Journal of Immunology 187, 5887-5900.

Fu M, Li L, Albrecht T, Johnson JD, Kojic LD, Nabi IR (2011) Autocrine molility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release. Cell Death and Differentiation 18, 1057-1070.

Johnson JD, Bround M, White SA, Luciani DS (2011) Nanospaces between endoplasmic reticulum and mitochondria as control centers of pancreatic β-cell metabolism and survival. Protoplasma 249, Suppl. 1:S49-58.

Lee KT, Karunakaran S, Ho MM, Clee SM (2011) PWD/PhJ and WSB/EiJ mice are resistant to diet induced obesity but have abnormal insulin secretion. Endocrinology 152, 3005-3017.

Machtaler S, Dang-Lawson M, Choi K, Jang C, Naus CC, Matsuuchi L (2011) The gap junction protein Connexin43 (Cx43) regulates B-lymphocyte spreading and adhesion. Journal of Cell Science 124, 2611-2621.

Maltby S, Freeman SA, Gold MJ, Baker JH, Minchinton AI, Gold MR, Roskelley CD, McNagny KM (2011) Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration. PLoS One 6(4):e18160.

Meissner B, Rogalski T, Viveiros R, Warner A, Plastino L, Lorch A, Granger L, Segalat L, Moerman DG (2011) Subcellular localization of proteins within Caenorhabditis elegans body wall muscle. Plos One 6:e19937.

Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley CD, Overall C (2011) Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: the role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis. Journal of Biological Chemistry 286, 34271-34285.

Petit A, Sanders AD, Kennedy TE, Tetzlaff W, Glattfelder KJ, Dalley RA, Puchalski RB, Jones AR, Roskams AJ (2011) Adult spinal cord radial glia display a unique progenitor phenotype. PLoS One 6(9):e24538.

Pines M, Fairchild MJ, Tanentzapf G (2011) Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis. Developmental Dynamics 240, 36-51.

Ribeiro I, Yuan L, Tanentzapf G, Dowling JJ, Kiger A (2011) Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. PLoS Genetics 7(2):e1001295.

Shin JJ, Loewen CJ (2011) Putting the pH into phosphatidic acid signaling. BMC Biology 9, 85.

Szabat M, Kalynyak TB, Lim GE, Chu KY, Yang YH, Asadi A, Gage BK, Ao Z, Warnock GL, Piret JM, Kieffer TJ, Johnson JD (2011) Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes. Cell Death and Disease 2:e232.

Tham DKL, Moukhles H (2011) Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix. American Journal of Physiology: Renal Physiology 301, F396-409.

Veverytsa L, Allan DW (2011) Retrograde BMP-signaling controls Drosophila behavior through regulation of a peptide hormone battery. Development 138, 3147-3157.

Viveiros R, Hutter H, Moerman DG (2011) Novel membrane extensions are required for proper anterior migration of muscle cells during Caenorhabditis elegans embryogenesis. Developmental Biology 358, 189-200.

Yang YHC, Szabat M, Bragagnini C, Kott K, Helgason CD, Hoffman BG, Johnson JD (2011) Paracrine signaling loops in adult pancreatic islets: Netrins modulate beta-cell apoptosis via Neogenin and Unc5a. Diabetologia 54, 828-842.

Zheng YZ, Boscher C, Inder KR, Fairbank MR, Loo DR, Hill MM, Nabi IR, Foster LJ (2011) Differential impact of caveolae and caveolin-1 scaffolds on the membrane raft proteome. Molecular and Cellular Proteomics 10, M110.007146.


2010

Alejandro EU, Kalynyak TB, Taghizadeh F, Gwiazda KS, Rawstron EK, Jacob KJ, Johnson JD (2010) Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf1 dependent pathways. Endocrinology 151, 502-512.

Chiu CG, Griffith OL, Strugnell S, Nabi IR, Gown A, Walker B, Wiseman SM (2010) Diagnostic utility of galectin-3 in thyroid cancer. American Journal of Pathology 176, 2067-2081.

Daoust J, Fontana A, Merchant CE, de Voogd N, Kieffer TJ, Andersen RJ (2010) Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteomarginata and the sponge Phorbas sp. collected in British Columbia activates the cAMP cell signaling pathway. Organic Letters 12, 3208-3211.

Ellis SJ, Tanentzapf G (2010) Integrin-mediated adhesion and stem-cell-niche interactions. Cell and Tissue Research 339, 121-130.

Franco-Cea A, Ellis SJ, Fairchild MJ, Yuan L, Cheung TY, Tanentzapf G (2010) Distinct developmental roles for direct and indirect talin-mediated linkage to actin. Developmental Biology 345, 64-77.

Freeman SA, McLeod SJ, Dukowski J, Austin P, Millen-Martin B, Kubes P, McCafferty DM, Gold MR, Roskelley CD (2010) Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. Cancer Research 70, 4590-4601.

Gage B, Riedel M, Karanu F, Rezania A, Fujita Y, Webber T, Baker R, Wideman R, Kieffer T (2010) Cellular reprogramming of human amniotic fluid cells to express insulin. Differentiation 80, 130-139.

Garside VC, Kowalik AS, Johnson CL, DiRenzo D, Konieczny SF, Pin CL (2010) MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding Secretory Pathway Calcium ATPase 2. Experimental Cell Research 316, 2859-2870.

Hankins JS, Denroche HC, Mackie GA (2010) Interactions of the RNA-binding protein Hfq with cspA mRNA, encoding the major cold shock protein. Journal of Bacteriology 192, 2482-2490.

Hill JA, Szabat M, Hoesli CA, Gage BK, Yang YH, Williams DE, Riedel MJ, Luciani DS, Kalynyak TB, Tsai K, Ao Z, Andersen RJ, Warnock GL, Piret JM, Kieffer TJ, Johnson JD (2010) A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate Insulin and Pdx1 expression. PLoS One 5(9):e12958.

Huynh FK, Levi J, Gray SL, Voshol PJ, Denroche HC, Speck M, Chua SC, Covey SD, Kieffer TJ (2010) Disruption of hepatic leptin signaling protects mice from age-related glucose intolerance. Diabetes 59, 3032-3040.

Joshi B, Li L, Nabi IR (2010) A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase. Journal of Biological Chemistry 285, 8830-8839.

Karamboulas K, Dranse H, Underhill TM (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFβ signals. Journal of Cell Science 123, 2068-2076.

Lin KBL, Freeman SA, Gold MR (2010) Rap GTPase-mediated adhesion and migration: A target for limiting the dissemination of B-cell lymphomas? Cell Adhesion and Migration 4, 327-332.

Lin KBL, Tan P, Freeman SA, Lam M, McNagny KM, Gold MR (2010) The Rap GTPases regulate the migration, invasiveness, and in vivo dissemination of B-cell lymphomas. Oncogene 29, 608-615.

Perkins AD, Ellis SJ, Asghari P, Shamsian A, Moore EDW, Tanentzapf G (2010) Integrin-mediated adhesion maintains sarcomeric integrity. Developmental Biology 338, 15-27.

Scriven DRL, Asghari P, Schulson MN, Moore EDW (2010) Analysis of Cav 1.2 and ryanodine receptor clusters in rat ventricular myocytes. Biophysical Journal 99, 3923-3929.

Young BP, Shin JJ, Orij R, Chao JT, Li SC, Guan XL, Khong A, Jan E, Wenk MR, Prinz WA, Smits GJ, Loewen CJ (2010) Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism. Science 329, 1085-1088.

Yuan L, Fairchild MJ, Perkins AD, Tanentzapf G (2010) Analysis of integrin turnover in fly myotendinous junctions. Journal of Cell Science 123, 939-946.
2009

Asghari P, Schulson M, Scriven DRL, Martens G, Moore EDW (2009) Axial tubules of rat ventricular myocytes form multiple junctions with the SR. Biophysical Journal 96, 4651-4660.

Chao JT, Foster LJ, Loewen CJ (2009) Identification of protein complexes with quantitative proteomics in S. cerevisiae. Journal of Visualized Experiments 4, pii:1225. doi: 10.3791/1225.

Cheung TYS, Fairchild MJ, Zarivach R, Tanentzapf G, Van Petegem F (2009) Crystal structure of the talin integrin binding domain 2. Journal of Molecular Biology 387, 787-793.

Chopra N, Yang T, Asghari P, Moore EDW, Huke S, et al. (2009) Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proceedings of the National Academy of Sciences USA 106, 7636-7641.

Chou A, Boerkoel C, du Souich C, Rupps R (2009) Phenotypic and molecular characterization of a novel DCX deletion and a review of the literature. Clinical Genetics 76, 214-218.

Cina C, Theis M, Willecke K, Maass K, Bechberger JF, Naus CC (2009) Involvement of the C-terminal of Connexin43 in neuronal migration. Journal of Neuroscience 29, 2009-2021.

De Vuyst E, Doecrock E, De Bock M, Van Moorhem M, Lai CP, Yamasaki H, Naus CC, Evans WH, Leybaert L (2009) Calcium-activation and inactivation of ATP release via connexin43 hemichannels is controlled by a calmodulin-arachidonic acid-ROS/NO signaling cascade. Cell Calcium 46, 176-187.

Decrock E, De Vuyst E, Vinken M, Van Moorhem M, Vranckx K, Wang N, Van Laeken L, De Bock M, D’Herde K, Lai CP, Rogiers V, Evans WH, Naus CC, Leybaert L (2009) Connexin43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. Cell Death & Differentiation 16, 151-163.

du Souich C, Chou A, Yin J, Oh T, Nelson TN, Hurlburt J, Arbour L, Friedlander R, McGillivray BC, Tyshchenko N, Rump A, Poskitt KJ, Demos MK, Van Allen MI, Boerkoel CF (2009) Characterization of a new X-linked mental retardation syndrome with microcephaly, cortical malformation, and thin habitus. American Journal of Medical Genetics A 149A, 2469-2478.

Eade KT, Allan DW (2009) Neuronal phenotype in the mature nervous system is maintained by persistent retrograde bone morphogenetic protein signaling. Journal of Neuroscience 29, 3852-3864.

Fairbank M, St-Pierre P, Nabi IR (2009) The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase. Molecular Biosystems 5, 793-801.

Forestieri R, Merchant CE, de Voogd NJ, Matainaho T, Kieffer TJ, Andersen RJ (2009) Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway. Organic Letters 11, 5166-5169.

Gwiazda KG, Yang TLB, Lin Y, Johnson JD (2009) Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells. American Journal of Physiology 296, E690-E701.

Lai CP, Bechberger J, Naus CC (2009) Panx2 as a novel growth suppressor in C6 glioma cells. Oncogene 28, 4402-4408.

Lajoie P, Kojic LD, Nim S, Li L, Dennis JW, Nabi IR (2009) Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B subunit occurs independently of caveolae. Journal of Cellular and Molecular Medicine 13, 3218-3225.

Luciani DS, Gwiazda KG, Yang TLB, Kalynyak TB, Bychkivska Y, Frey MHZ, Jeffrey KD, Sampaio AV, Underhill MT, Johnson JD (2009) Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes 58, 422-432.

Noël G, Tham DKL, Moukhles H (2009) Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes. Journal of Biological Chemistry 284, 19694-19704.

Sin W-C, Moniz DM, Ozog MA, Tyler JE, Numata M, Church J (2009) Regulation of early neurite morphogenesis by the Na+/H+ exchanger NHE1. Journal of Neuroscience 29, 8946-8959.

Sun Y, Aiga M, Yoshida E, Humbert PO, Bamji SX (2009) Scribble interacts with β-catenin to regulate the localization of synaptic vesicles. Molecular Biology of the Cell 20, 3390-3400.

Tavassoli S, Chao JT, Loewen CJ (2009) A high-throughput method to globally study organelle morphology in S. cerevisiae. Journal of Visualized Experiments 2, pii:1224. doi: 10.3791/1224.

Young JS, Guttman JA, Vaid KS, Vogl AW (2009) Cortactin (CTTN), N-WASP (WASL) and clathrin (CLTC) are present at podosome-like tubulobulbar complexes in the rat testis. Biology of Reproduction 80, 153-161.

Young JS, Guttman JA, Vaid KS, Shahinian H, Vogl AW (2009) Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testis. Biology of Reproduction 80, 162-174.


2008

Lin KB, Freeman SA, Zabetian S, Brugger H, Weber M, Lei V, Dang-Lawson M, Tse KW, Santamaria R, Batista FD, Gold MR (2008) The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands. Immunity 28, 75-87.
2007

Bates D, Sin W-C, Aftab Q, Naus CC (2007) Connexin43 enhances glioma invasion by a mechanism involving the carboxy terminus. Glia 55, 1554-1564.

Cina C, Bechberger JF, Ozog MA, Naus CC (2007) Expression of connexins in embryonic mouse neocortical development. Journal of Comparative Neurology 504, 298-313.

Hunt-Newbury R, Viveiros R, Johnsen R, Mah A, Anastas D, Fang L, Halfnight E, Lee D, Lin J, Lorch A, McKay S, Okada HM, Pan J, Schulz AK, Tu D, Wong K, Zhao Z, Alexeyenko A, Burglin T, Sonnhammer E, Schnabel R, Jones SJ, Marra MA, Baillie DL, Moerman DG (2007) High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. PLoS Biology 5:e237.

Lai CPK, Bechberger JF, Thompson R, MacVicar B, Bruzzone R, Naus CC (2007) Tumour suppressive effects of Panx1 in C6 glioma cells. Cancer Research 67, 1545-1554.

Loewen CJ, Young BP, Tavassoli S, Levine TP (2007) Inheritance of cortical ER in yeast is required for normal septin organization. Journal of Cell Biology 179, 467–483.

McCoy ML, Zhou L, MacDonald G, Mueller CR, Roskelley CD (2007) Regulation of the BRCA1 promoter in ovarian surface epithelial cells and ovarian carcinoma cells. FEBS Letters 581, 1825-1833.

Nielsen JS, McCoy ML, Chelliah S, Vogl AW, Roskelley CD, McNagny KM (2007) The CD34-related molecule Podocalyxin is a potent inducer of microvillus formation. PLoS One 2:e237.