In order to supervise a student in the CELL Program, a faculty member must be a member of the Program. The following are current members of the CELL Program who are eligible to supervise students in the Program. If you wish to enroll in the CELL Program and have identified a potential research supervisor whose name does not appear below, please discuss with your prospective research supervisor the possibility of him or her becoming a faculty member of the CELL Program. Information can be found here.
Molecular mechanisms responsible for cellular pacemaking behaviour and that underlie the function and expression of “pacemaker” channels
Tel: (604) 822-6900
Differentiation and maintenance of neuronal identity in Drosophila melanogaster, using molecular genetic, biochemical and bioinformatic approaches to examine the roles and intersection of intrinsic transcription factor codes and target-derived signals.
Tel: (604) 827-5960
The molecular interactions between glia and neurons that occur during development of the nervous system of Drosophila. The development of permeability barriers in polarized epithelia and glia and the formation of the septate and tricellular junctions.
Tel: (604) 822-1977
Molecular mechanisms underlying synapse formation, maintenance and elimination; role of cell adhesion molecules at the synapse.
Tel: (604) 822-4746
A major focus of my lab investigates both the cellular and molecular processes that direct trophoblast cell biology in early placental development. Utilizing state of the art cell isolating techniques and three-dimensional culture systems.
We aim to understand how the brain forms, stores, and retrieves memories. To do this, we take a multidisciplinary, multiscale approach. We combine big data analysis and cutting-edge experimental techniques to study memory across the spatial scales of the nervous system: molecules, cells, circuits, and behaviour. With this combination, we aim to generate a comprehensive understanding of the neurobiological rules of memory in both health and disorder.
Tel: (604) 822-3463
Identification of regulatory proteins that control vesicle transport and contribution of defects in protein and lipid trafficking to human disease.
Tel: (604) 875-3898
Mathematical and computational models of immune cell signalling. Confocal microscopy and single particle tracking for membrane receptors. Population dynamics of HIV virus in vivo.
Tel: (604) 822-2859
Dong lab studies the molecular biology of the androgen receptor and RNA splicing factors that regulate prostate cancers to develop resistance to anti-cancer therapy. The ultimate goal of our research is to develop novel therapies and improve existing treatments for therapy resistant prostate cancers. We enjoy inspiring young investigators to practice biomedical research, and always welcome ambitious and self-driven young scientists who have strong passion for research to join us.
Transcription and RNA splicing regulation of therapy-resistant prostate cancer progression.
Tel: (604) 875-4111 ext 63020
Modeling the roles of small GTPases in eukaryotic cell polarization and motility, the actin cytoskeleton, and patterns such as actin waves. Models for microtubule-associated motor protein transport, single-cell wound healing, Rac signaling, and the role of cofilin in mammary carcinoma motility.
Tel: (604) 822-5889
B cell development, survival, activation and migration.
Tel: (604) 822-4070
Organization, function, and development of neural circuits that process sensory information in the fruit fly brain.
Tel: (604) 827-4854
Understanding developmental and degenerative pathologies associated with cartilage, bone, and tooth formation: from craniofacial development to osteoarthritis and fracture healing.
Mechanisms underlying RNA storage and translational control during oocyte development. Understanding the molecular basis for reproductive aging and meiotic failure.
Tel: (604) 827-0907
Neuronal plasticity during early brain development. Activity-dependent synaptogenesis and dendritic arbor growth with the intent of understanding how brain neurons establish complex morphologies and inter-neuronal connections to create functional brain circuits.
Tel: (604) 822-9770
Mechanisms of oral and epidermal wound healing.
Tel: (604) 822-0096
Steroids in growth and development.
Tel: (604) 822-2498
We seek to develop neuroregenerative and neuroprotective therapies that enable meaningful functional improvements in individuals with spinal cord injury. We use a multidisciplinary research strategy combining cellular, molecular, and bioinformatic approaches together with tissue clearing and 3D imaging analyses in order to identify the processes that prevent damaged axons from regenerating. We are also interested in identifying the cells and circuits that are most important for mediating functional improvements after injury.
Genetic and epigenetic mechanisms that control the transcriptional networks that drive endocrine pancreas development, function, and proliferation.
Tel: (604) 875-2000 ext. 4794
Early events in mammalian development and the signalling pathways that regulate these processes.
Tel: (604) 675-8133
Integrated physiology, from organelle to organism, in the pathogenesis of diabetes, obesity, heart disease, cancer and neurodegeneration.
Tel: (604) 822-7187
Tim Kieffer Dept. of Cellular & Physiological Sciences, Faculty of Medicine.
The development of novel therapeutic approaches to diabetes using molecular, cellular and physiological techniques.
Tel: (604) 822-2156
Identifying the molecular mechanisms underlying cell fate commitment in the pancreas and their relationship to the development of pancreatic cancer.
Tel: (604) 827-0626
Combining developmental biology and human genetics to understand how metabolic cells normally develop and how defects in this process leads to disease.
Tel: (604) 822-2163
Proteomics, bioinformatics and cell signalling in childhood cancer. Development of proteomics methods and new approaches for better treatment and diagnostics in paediatric malignancies.
Tel: (604) 875-2000 ext. 6015
DNA replication, epigenetics and stem cells; Telomeres, genomic instability, aging and cancer; Genetic analysis using single cell Strand-seq.
Tel: (604) 675-8135
Plant molecular genetics and genomics, specifically to understand the natural resistance mechanisms of plants against broad-spectrum of pathogens including fungi, bacteria, and viruses.
Tel: (604) 822-3155
Cellular biology and molecular mechanisms governing integrin-mediated adhesion and motility in childhood cancers.
Tel: (604) 875-2000 ext. 4795
Mechanisms underlying interactions between the endoplasmic reticulum and other organelles.
Tel: (604) 827-5961
The normal physiology of insulin secreting pancreatic beta-cells, as well as the sub-cellular mechanisms that mediate failure and death of the beta-cells in diabetes.
Tel: (604) 875-2000 ext. 6170
Mechanisms that regulate the formation of islet β-cells from pancreatic stem or progenitor cells. We focus on the gene regulatory networks at play in the progenitor cells and how these networks change during differentiation to mature endocrine cells and in the long-term maintenance of the β-cell.
Tel: (604) 875-2000 ext. 5426
Translational research on retinal diseases and treatment strategies.
Tel: (604) 875-4383
Receptor assembly and protein trafficking in lymphoid cells. Cell secretion. Signaling by the B cell antigen receptor.
Tel: (604) 822-4881
Microtubule organization during cell division and differentiation and its relationship to childhood and adult cancers.
Tel: (604) 875-2000 ext. 4691
The Mizumoto lab is studying various aspects of the neurodevelopment such as synapse pattern formation and neuronal patterning using C. elegans as a model system. We use a combination of classic and advanced genetics, molecular biology and microscopy.
Tel: (604) 827-0794
The assembly and organization of myofilaments within the body wall muscle of C. elegans. RNA and protein expression profiles in specific tissues and cells, and developmental stages of C. elegans.
Tel: (604) 822-3365
The investigation of structure-function relationships in cardiac muscle using microscopic and biochemical techniques.
Tel: (604) 822-3423
Biochemistry and cell biology of the mechanisms underlying genetically inherited forms of blindness. Mechanisms of protein trafficking within photoreceptor cells, and how these mechanisms relate to these genetic disorders.
Tel: (604) 875-4357
Role of dystroglycan, a protein associated with several forms of muscular dystrophy, in the central nervous system. Mechanisms underlying the dystroglycan-mediated targeting and polarized distribution of potassium and water-permeable channels in astrocytes.
Tel: (604) 822-7882
Tim Murphy is a basic scientist who contributes to understanding of how mouse cortex adapts after stroke, resulting in remapping of brain function from damaged to surviving areas using mouse models. The lab develops new imaging and optogenetic methods that have parallels to human brain imaging and stimulation tools. In developing these tools that laboratory participates in the Canadian Neurophotonics Platform and leads UBC’s Dynamic Brain Circuits in Health and Disease Cluster which actively seeks to articulate new optical methods that are applied to questions related to diseases of the nervous system. Murphy has been a past instructor in the Cold Spring Harbor Laboratory Imaging Neurons and Neural Activity course and UBC’s 3D-microscopy courses. By understanding the stroke recovery process on a circuit level, the lab hopes to advance patient translatable brain stimulation or other plasticity-inducing treatments. More recently the laboratory has extended these approaches to mouse models of psychiatric disorders such as depression and autism. To facilitate circuit interrogation in vivo the lab develops high-throughput models which automate animal imaging.
Tel: (604) 822-0705
Cancer cell biology, membrane domains, organelle contact sites, super-resolution microscopy, machine learning, tumor cell migration and metastasis.
Tel: (604) 822-7000
Gap junctions in neural development and disease.
Tel: (604) 827-4383
Molecular mechanisms of neuronal outgrowth, guidance and directed growth. Remodeling of the cytoskeleton during neurite outgrowth.
Tel: (604) 822-9759
Molecular mechanisms of nuclear import of macromolecules and viruses.
Tel: (604) 822-3369
The Plotkin lab’s current developmental biology interests focus on the molecular genetic origins of multicellularity. They investigate the function and evolution of genetic regulatory networks (GRNs) involved in the processes of cell differentiation, wherein they observe and quantify how such GRNs can give rise to differential gene expression and ultimately to different cell fates. To study the genes and mechanisms inducing cell differentiation that are conserved across all multicellular animal species, their model organism is the ctenophore Mnemiopsis leidyi, a candidate for the earliest diverging animal on the phylogenetic tree.
Tel: (604) 822-8813
Reactions of the nervous system to trauma (nerve and spinal cord injuries), with particular emphasis on sensory processing and pain.
Behavioural, cellular and molecular mechanisms involved in learning and memory.
Tel: (604) 822-5449
Cellular and synaptic mechanisms of Huntington disease pathophysiology, including changes in striatal NMDA-type glutamate receptor trafficking/function and synaptic plasticity. Combined brain imaging with optogenetic techniques and behavioural testing in animal models of neurological disease.
Tel: (604) 822-0723
Craniofacial development and evolution.
Tel: (604) 822-3568
Genetic, molecular and physiological mechanisms underlying male-female differences in body size, metabolism and stress responses in Drosophila.
Tel: (604) 822-0623
Immune Regulation of Developmental programs.
Tel: (604) 822-0806
Regulation of tissue architecture during breast and ovarian carcinoma progression.
Tel: (604) 822-0779
Plant cell biology. Cellular basis of secretion of plant cell wall components.
Tel: (604) 822-3554
Understanding how cell recognizes different sets of environmental cues to specify cell division orientation during embryogenesis. How cell division timings are coordinated during organogenesis of C. elegans intestine.
Integrin function in morphogenesis. Determination of how cells come together to form complex structures and then, once formed, how such structures are maintained.
Tel: (604) 827-4334
How changes in transcriptional networks contribute to pathologic changes.
Tel: (604) 875-3860
The retinoid signaling pathway in chondrogenesis and osteogenesis. Mechanisms underlying the commitment and differentiation of skeletal progenitors.
Tel: (604) 822-5833
Arrangement, function and control of cytoskeletal systems in cells.
Tel: (604) 822-2395
Growth and development of craniofacial and dental tissues occurs via a sequence of complex cellular interactions that are controlled by a myriad of genetic, epigenetic and molecular events. Our research focuses on different aspects of normal and abnormal craniofacial and dental development; ranging from morphological analysis of growth and asymmetries, molecular events involved in tooth shape and structure, to outcomes-based clinical assessment of surgical outcomes.
Tel: (604) 827-5575
Understanding the pathways and mechanisms by which cells regulate mitochondrial homeostasis during stress.
Improved detection, diagnosis, and treatment for cancer patients are the overarching research goals of the Williams lab. The Williams lab studies tumor cell fragments called extracellular vesicles (EVs) to identify how they support and promote tumor growth and dissemination. EVs can also be used to detect and report on cancer, and we are using EVs to develop ‘liquid biopsies’ capable of reporting on an individual’s cancer. We also study invasion promoting structures termed invadopodia to understand how cancer spreads and to develop new therapies focused on impairing or stabilizing metastatic disease.
Tel: (604) 822-9915
Stem cells in the treatment of ocular surface diseases and age-related macular degeneration.